PANTERA acknowledges how regions are important to achieve the project’s objectives. This is how the concept of Regional Desks was created. We will set up and coordinate Regional Desks so that their operation is fully aligned with the national/regional research and innovation strategy for smart specialisation (RIS3) in content and approach. RIS3 is a critically important activity that will support the PANTERA process through collaborative work within the regions, as will be analysed within the following booklet.